Many celebrities have shed a significant amount of weight, and in many instances, a GLP-1 is behind this. Talk about Ozempic does appear and it is now a part of their everyday lives.
Four of these super-popular celebrities spoke about losing weight this year, through pills, proprietary programs, and something in between.
#1: Oprah Winfrey
Oprah Winfrey has recently talked about losing weight. In a recent personal interview with the magazine people, she discussed her own weight loss as well as a book release: Enough: Your Health, Your Weight and What It’s Like to Be Free. The name of the book really does say it all.
She was 71 when she revealed that she had begun a regimen of a GLP-1 drug in 2023. She continued that regimen for about six months before she stopped it. Not because it wasn’t working, mind you, but because she wanted to find out whether she could lose weight on her own, using just food, exercising, discipline – that kind of stuff. It didn’t go that well. She said she even regained about 20 pounds just using food and exercise.
“This will be a lifetime process,” she said, no sugarcoating. She likened it to blood pressure medicine. When she stopped that, her numbers just rose again. The principle is the same in this case, she understood. It’s a process she said she’s tested on herself, the results are clear. No need for drama, she just stated facts.
In explaining, she also said that a weight of 211 pounds was not even healthy, though it was a normal weight for her. She is actually a pre-diabetic. High cholesterol is also an issue.
Once, she told People magazine she injected a GLP-1 every week. It’s just what she does. Even her friends have to pitch in to get it if they want it. It’s mentioned almost casually.
The largest difference, in her opinion, was the lack of desire for food, a constant strength and it all seems to get along, leading her to great results.
#2: Amy Schumer
Once the photos began leaking, the online community started speculating. She quashed this speculation in a since-deleted post on Instagram. Fixed the weight loss first. It was not 30 pounds, but 50. She went on to claim she doesn’t do Botox or fillers either. She just lays it out there.
There were side-by-side photos everywhere. One from May 2024, and one from 2025. Before and after, like it always turns out.
Schumer emphasized that the new approach wasn’t about appearances. It was about survival. She confirmed she took the drug Mounjaro.
“Not to look hot,” she said, adding that part which is nice, but it’s just temporary. Survival was the point. She spoke about how the illness caused her face to swell up, how dangerous it can be, and how the internet picked up on it before she could correct the problem.
She apologized for whatever feelings she may have caused others with her weight loss. Then she gave some much-needed context. She had plastic surgery previously. She is a Mounjaro dieter. She is pain free. She can run around and play games with her son.
She also talked about hormones. Perimenopause. Said she’s game for discussing more about it, if people are genuinely interested in learning about what she’s been experiencing, what’s happening in her body, where she’s at with everything.
#3 – Meghan Trainor
Even Meghan Trainor has had to contend with the fallout. After shedding a reported 60 pounds, the “All About That Bass” singer found herself on the receiving end of a healthy dose of body shaming – but rather than take it lying down, she called the body shamers out.
Recently, she had this to say to Entertainment Tonight: “I’m feeling better than I have in a very, very long time. Better than ever. This is the first time I’ve concentrated on my health since having two kids. And oddly, the criticism has exacerbated at this point. The criticism gets worse. Louder. Meaner. The more that I’m feeling good, the more that people come at me. But what I continue to make clear and continue to point out is that the focus isn’t on them.”
“I’m taking care of myself,” she repeated. And then confessed that the difficult thing is finding a way not to let the noise get under her skin.
Her health transformations did not begin with taking any medications. They began with her diet. She began eliminating gluten and dairy because she realized she had a condition she calls ‘leaky gut.’ At the same time, she seriously started working on strength training. Not casually, not occasionally here and there. Seriously committing to it.
GLP-1s are beneficial, yes, but they are not an action plan on their own, according to Maher, which is why the plan works, according to the trainer.
#4: Lizzo
Lizzo appeared this year with a slimmed-down figure, and people quickly started speculating. The GLP-1 acronym naturally popped up. It always does. She didn’t dodge questions when her weight loss was mentioned on a podcast called Just Trish with Trisha Paytas in June last year.
“She said she’d tried everything,” diets, strategies, all the work. Of course, she was talking about Ozempic, but she got right to it. “It works because you eat less,” she said. “
She also talked about a few changes in her eating patterns that really did stick. Giving up her vegan diet was one such thing. Eating more meat helped her remain in a calorie deficit, which is what she said. Before that, she said she was consuming a lot of fake meat, bread, and rice. A lot of it because she wanted to feel full. She said that she was averaging between 3,000 and 5,000 calories.
Eating real foods helped. Beef. Chicken. Fish. Foods that really filled her up and didn’t make her stomach feel like it was going to burst open. And she told us she wasn’t eating like she was trying to starve herself by eating things that looked like food but really filled nothing.
The greatest motive, however, had little to do with looking good. Pain. Back pain. After the shows, boy. She spoke of wanting to be around for a long time – not just at this stage in her life but in 30 years. She wants to be Tina Turner. Still touring stadiums at 70 years old. And if her back endures as it does now, there’s no way that’s happening.
